منابع مشابه
Conserved non-coding elements: developmental gene regulation meets genome organization
Comparative genomics has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree of conservation between two or more organisms, regularly exceeding that found within protein-coding exons. These elements, collectively referred to as conserved non-coding elements (CNEs), are non-randomly distributed across chromosomes and tend to cluster in the vicinity of ge...
متن کاملAutomating Gene Expression Annotation for Mouse Embryo
It is of high biomedical interest to identify gene interactions and networks that are associated with developmental and physiological functions in the mouse embryo. There are now large datasets with both spatial and ontological annotation of the spatio-temporal patterns of geneexpression that provide a powerful resource to discover potential mechanisms of embryo organisation. Ontological annota...
متن کاملAnnotation confidence score for genome annotation: a genome comparison approach
MOTIVATION The massively parallel sequencing technology can be used by small research labs to generate genome sequences of their research interest. However, annotation of genomes still relies on the manual process, which becomes a serious bottleneck to the high-throughput genome projects. Recently, automatic annotation methods are increasingly more accurate, but there are several issues. One im...
متن کاملLarge-scale prokaryotic gene prediction and comparison to genome annotation
MOTIVATION Prokaryotic genomes are sequenced and annotated at an increasing rate. The methods of annotation vary between sequencing groups. It makes genome comparison difficult and may lead to propagation of errors when questionable assignments are adapted from one genome to another. Genome comparison either on a large or small scale would be facilitated by using a single standard for annotatio...
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Since the structure of the DNA molecule was identified half a century ago, the complete genome sequence has been determined for 37 prokaryotes and several eukaryotes. With the exponential growth of genetic information, bioinformatics has attempted to predict gene locations and functions in cyberspace prior to experimental confirmation at the bench.
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 1999
ISSN: 1061-4036,1546-1718
DOI: 10.1038/14236